Tuesday, 27 January 2015

Clostridium difficile

Evidence Based Reports

A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE)(2014)[NHS EED] NEW

Fecal Bacteriotherapy for Adult Patients with Recurrent Clostridium difficile infection: Update of Clinical and Cost-Effectiveness, and Guidelines (2014)[HTA database] NEW

Probiotics for Antibiotic-Associated Diarrhea, Clostridium difficile Infection and Irritable Bowel Syndrome: A Review of Clinical Evidence and Safety (2014)[HTA database] NEW

Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. (2013) [DARE]

Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. (2013) [DARE]

Clostridium difficile infection: fidaxomicin (2012) [NICE] NEW

Fidaxomicin for clostridium difficile-associated diarrhoea: epidemiological method for estimation of warranted price (2012) [NHS EED]

Is primary prevention of Clostridium difficile infection possible with specific probiotics? (2012) [DARE]

Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. (2012) [DARE] NEW

The potential economic value of screening hospital admissions for Clostridium difficile. (2012) [NHS EED]

Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis. (2012) [DARE]

Comparative effectiveness of Clostridium difficile treatments: a systematic review. (2012) [DARE]

Fidaxomicin (Dificlir)- treatment of adults with clostridium difficile. (2012) [Scottish Medicines Consortium]

Antibiotic treatment for Clostridium difficile-associated diarrhea in adults (2011)[Cochrane Library]

Probiotics for prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adults--a meta-analysis. (2011)[DARE]

Prevention of Clostridium difficile infection with Saccharomyces boulardii: a systematic review (2009)[DARE]

Clinical Guidelines

Faecal microbiota transplant for recurrent Clostridium difficile infection (2014)[NICE interventional procedure guidance] NEW

Clostridium difficile infection: how to deal with the problem (2009) [DoH]

Recent articles in core journals

Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection (2014)[JAMA] NEW

Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. (2013) [Lancet]

Evaluation of the national Cleanyourhands campaign to reduce Staphylococcus aureus bacteraemia and Clostridium difficile infection in hospitals in England and Wales by improved hand hygiene: four year, prospective, ecological, interrupted time series study. (2012) [BMJ]

Using a dog's superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study. (2012) [BMJ]

Vancomycin or Metronidazole for Treatment of Clostridium difficile Infection: Clinical and Economic Analyses. (2011) [EvidenceUpdates]

Host and pathogen factors for Clostridium difficile infection and colonization. (2011) [NEJM]

Prevention of endemic healthcare-associated Clostridium difficile infection: reviewing the evidence.(2010)[EvidenceUpdates]

Clostridium difficile infection in Europe: a hospital-based survey. (2010)[Lancet]

In the clinic. Clostridium difficile Infection. (2010)[Annals of Internal Medicine]

Reducing Clostridium difficile infection in acute care by using an improvement collaborative. (2010)[BMJ]

Proton pump inhibitors and risk for recurrent Clostridium difficile infection. (2010)[EvidenceUpdates]

Treatment with monoclonal antibodies against Clostridium difficile toxins. (2010)[NEJM]

Does my patient have Clostridium difficile infection? (2009)[Annals of Internal Medicine]

Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection.(2009)[EvidenceUpdates]

A 76-year-old man with recurrent Clostridium difficile-associated diarrhea: review of C. difficile infection. (2009)[JAMA]


Clostridium Difficile Colitis (2014)[eMedicine] updated

Clinical Queries

What is the evidence for the link between proton pump inhibitor usage and the development of Clostridium Difficile infection? (2008) [TRIPanswers]

Is there any evidence to link antibiotic prescribing in primary care with cases of clostridium difficile in the community setting? (2007) [TRIPanswers]

How long does clostridium difficile toxin remain positive in stool sample after treatment? (2007) [TRIPanswers]

Should people with hospital acquired clostridium difficile have their PPI withheld to help prevent recurrence? (2006) [TRIPanswers]

Patient Information

Clostridium difficile (2014)[BUPA] updated

Clostridium difficile (2014)[NHS Choices] updated

Clostridium Difficile (2012)[Patient UK]


1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

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