Evidence Based Reports
Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome (2014)[Cochrane Library] NEW
Aromatase inhibitors for subfertile women with polycystic ovary syndrome (2014)[Cochrane Library] NEW
Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS: A systematic review (2014)[DARE] NEW
In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction. (2013) [Cochrane Library]
Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. (2013) [DARE]
Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. (2012) [Cochrane Library]
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. (2012) [Cochrane Library]
Statins for women with polycystic ovary syndrome not actively trying to conceive (2011)[Cochrane Library]
Acupuncture for polycystic ovarian syndrome (2011)[Cochrane Library]
Chinese herbal medicine for subfertile women with polycystic ovarian syndrome (2010)[Cochrane Library]
PCOS (2009)[Clinical Evidence] subscription required
Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis (2009)[DARE]
Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials (2009)[DARE]
In vitro maturation in sub fertile women with polycystic ovarian syndrome undergoing assisted reproduction (2009)[Cochrane Library]
Aromatase inhibitors for infertility in polycystic ovary syndrome: the beginning or the end of a new era? (2009)[DARE]
The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review (2008)[DARE]
Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS (2008)[Cochrane Library]
Clinical Guidelines
Long-term Consequences of Polycystic Ovary Syndrome (2014)[RCOG] NEW
Polycystic ovary syndrome (2013)[CKS]
Recent articles in core journals
Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. (2013) [EvidenceUpdates]
Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study.(2011)[BMJ]
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis.(2011)[EvidenceUpdates]
Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial (2010)[EvidenceUpdates]
Use of Metformin in Polycystic Ovary Syndrome: A Meta-Analysis (2008)[EvidenceUpdates]
eTextbooks
Polycystic Ovarian Syndrome (2014)[eMedicine] updated
Polycystic Ovarian Syndrome (2013)[Mentor]
polycystic ovary syndrome (2010)[GPnotebook]
Clinical Queries
What effect does metformin have on obesity and the cardiovascular problems seen in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
How effective is metformin compared to co-cyprindiol/oral contraceptive pill in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
What effect does metformin have on hirsutism and acne in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
What effect does metformin have on insulin resistance or the development of diabetes in women with polycystic ovary syndrome? (2014)[UKMI] NEW
Which contraceptive method provides suitable endometrial protection for women with polycystic ovary syndrome (PCOS) and does the method differ by age? (2014)[FSRH] NEW
Do anovulatory methods of contraception reduce or halt the development of cysts in polycystic ovary syndrome (PCOS)? Furthermore many women with PCOS have a high BMI, is this a contraindication to the use of combined hormonal contraception (CHC) and if so which is the next best contraceptive method to ensure a bleed? (2014)[FSRH] NEW
Is there any evidence which identifies which contraceptive method is most effective for managing androgenic symptoms, especially hirsutism, in women with polycystic ovary syndrome who are breastfeeding? (2013) [FSRH]
Is there any evidence which identifies which contraceptive method is most effective for managing androgenic symptoms, especially hirsutism, in women with polycystic ovary syndrome who need contraception? (2013) [FSRH]
How long can metformin be prescribed for a woman who has PCOS, had 3 children, does not wish for more and non diabetic? (2012) [ATTRACT]
In PCOS patients how effective is metformin in the treatment of prediabetes? (2012) [ATTRACT]
Do any of the newer diabetic drugs [gliptins etc] have a role in weight reduction in PCOS? Is there any experience of use and are they licensed? (2011)[ATTRACT]
Should we continue to moniter lipids/glucose in a woman with PCOS who has had TAH/BSO (2011)[ATTRACT]
Patient Information
Polycystic ovary syndrome (PCOS0 (2012)[BUPA] updated
Polycystic Ovary Syndrome (2013)[PatientUK]
Polycystic ovary syndrome (2013)[NHS Choices]
Important
1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.
Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome (2014)[Cochrane Library] NEW
Aromatase inhibitors for subfertile women with polycystic ovary syndrome (2014)[Cochrane Library] NEW
Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS: A systematic review (2014)[DARE] NEW
In vitro maturation in subfertile women with polycystic ovarian syndrome undergoing assisted reproduction. (2013) [Cochrane Library]
Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. (2013) [DARE]
Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. (2012) [Cochrane Library]
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. (2012) [Cochrane Library]
Statins for women with polycystic ovary syndrome not actively trying to conceive (2011)[Cochrane Library]
Acupuncture for polycystic ovarian syndrome (2011)[Cochrane Library]
Chinese herbal medicine for subfertile women with polycystic ovarian syndrome (2010)[Cochrane Library]
PCOS (2009)[Clinical Evidence] subscription required
Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis (2009)[DARE]
Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials (2009)[DARE]
In vitro maturation in sub fertile women with polycystic ovarian syndrome undergoing assisted reproduction (2009)[Cochrane Library]
Aromatase inhibitors for infertility in polycystic ovary syndrome: the beginning or the end of a new era? (2009)[DARE]
The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review (2008)[DARE]
Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS (2008)[Cochrane Library]
Clinical Guidelines
Long-term Consequences of Polycystic Ovary Syndrome (2014)[RCOG] NEW
Polycystic ovary syndrome (2013)[CKS]
Recent articles in core journals
Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. (2013) [EvidenceUpdates]
Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study.(2011)[BMJ]
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis.(2011)[EvidenceUpdates]
Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial (2010)[EvidenceUpdates]
Use of Metformin in Polycystic Ovary Syndrome: A Meta-Analysis (2008)[EvidenceUpdates]
eTextbooks
Polycystic Ovarian Syndrome (2014)[eMedicine] updated
Polycystic Ovarian Syndrome (2013)[Mentor]
polycystic ovary syndrome (2010)[GPnotebook]
Clinical Queries
What effect does metformin have on obesity and the cardiovascular problems seen in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
How effective is metformin compared to co-cyprindiol/oral contraceptive pill in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
What effect does metformin have on hirsutism and acne in women with polycystic ovary syndrome? (2014)[WUKMI] NEW
What effect does metformin have on insulin resistance or the development of diabetes in women with polycystic ovary syndrome? (2014)[UKMI] NEW
Which contraceptive method provides suitable endometrial protection for women with polycystic ovary syndrome (PCOS) and does the method differ by age? (2014)[FSRH] NEW
Do anovulatory methods of contraception reduce or halt the development of cysts in polycystic ovary syndrome (PCOS)? Furthermore many women with PCOS have a high BMI, is this a contraindication to the use of combined hormonal contraception (CHC) and if so which is the next best contraceptive method to ensure a bleed? (2014)[FSRH] NEW
Is there any evidence which identifies which contraceptive method is most effective for managing androgenic symptoms, especially hirsutism, in women with polycystic ovary syndrome who are breastfeeding? (2013) [FSRH]
Is there any evidence which identifies which contraceptive method is most effective for managing androgenic symptoms, especially hirsutism, in women with polycystic ovary syndrome who need contraception? (2013) [FSRH]
How long can metformin be prescribed for a woman who has PCOS, had 3 children, does not wish for more and non diabetic? (2012) [ATTRACT]
In PCOS patients how effective is metformin in the treatment of prediabetes? (2012) [ATTRACT]
Do any of the newer diabetic drugs [gliptins etc] have a role in weight reduction in PCOS? Is there any experience of use and are they licensed? (2011)[ATTRACT]
Should we continue to moniter lipids/glucose in a woman with PCOS who has had TAH/BSO (2011)[ATTRACT]
Patient Information
Polycystic ovary syndrome (PCOS0 (2012)[BUPA] updated
Polycystic Ovary Syndrome (2013)[PatientUK]
Polycystic ovary syndrome (2013)[NHS Choices]
Important
1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.
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