Abdominal aortic aneurysm (AAA)

Evidence Based Reports

Endovascular Abdominal Aortic Aneurysm Repair versus Open Surgery: A Review of the Clinical and Cost-Effectiveness (2013)[CADTH] NEW

 

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness (2013)[NIHR HTA] NEW

 

Medical treatment for small abdominal aortic aneurysms (2012)[Cochrane] NEW

 Surgery for small asymptomatic abdominal aortic aneurysms (2012) [Cochrane] NEW

The UK EndoVascular Aneurysm Repair (EVAR) trials: randomised trials of EVAR versus standard therapy (2012)[NIHR HTA] NEW

Open versus endovascular stent graft repair of abdominal aortic aneurysms: a meta-analysis of randomized trials (2012)[DARE] NEW

Is there a difference in operative mortality between endovascular aneurysm repair and open surgery in elective abdominal aortic aneurysm? (2012)[Health Improvement Scotland] NEW

Endovascular stents for abdominal aortic aneurysms: a systematic review and economic model (2009)[NIHR HTA]

Endovascular stent - grafts for the treatment of abdominal aortic aneurysms (2009)[NICE]


Clinical Guidelines

Abdominal aortic aneurysm screening (2012)[Map of Medicine]

The UK NSC policy on Abdominal Aortic Aneurysm screening in men over 65 (2012)[UK NSC]

Framework for improving the results of elective AAA repair (2011) [Vascular Society]


Recent articles in core journals

Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial (2014) [BMJ] NEW

Immediate open repair vs surveillance in patients with small abdominal aortic aneurysms: survival differences by aneurysm size (2013)[Mayo Clinic Proceedings] NEW

Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening (2012) [Br J Surg] NEW

Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1(2011) [Br J Surg]

A randomized controlled trial of endovascular aneurysm repair versus open surgery for abdominal aortic aneurysms in low- to moderate-risk patients (2011) [J Vasc Surg]

The management of abdominal aortic aneurysms (2011)[BMJ]

Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm (2011)[Eur Heart J]

Long-term outcome of open or endovascular repair of abdominal aortic aneurysm (2010)[NEJM]

Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study (2009)[BMJ]


eTextbooks

Abdominal aortic Aneurysms (2012)[Mentor]


Clinical Queries

A 62 year old male patient with a strong family history of abdominal aortic aneurysm (AAA) (father and uncles) asked if he should undergo screening for AAA. What is the current advice and evidence for screening for AAA? (2010)[ATTRACT]


Patient Information

Repair of abdominal aortic aneurysm (2013)[NHS Choices] updated

Abdominal Aortic Aneurysm (2012)[BUPA]




Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Osteoarthritis

Evidence Based Reports

Physical Therapy for Knee Pain Secondary to Osteoarthritis: Future Research Needs (2013)[AHRQ] NEW

Knee Prostheses for Patellar Resurfacing for Adults with Osteoarthritis: Comparative Clinical Effectiveness (2012) [CADTH] NEW
 

Comparative Effectiveness Review : Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis (2012)[AHRQ] [Executive Summary] NEW

 

Clinician Research Summary: Analgesics for Osteoarthritis (2012)[AHRQ] NEW

 

Viscosupplementation for osteoarthritis of the knee (2012)[DARE] NEW

Kneehab® XP neuromuscular electrical stimulator for strengthening quadriceps muscles for knee surgery and osteoarthritis of the knee (2011)[NHSC]

Strontium ranelate (Protelos) for osteoarthritis (2011)[NHSC]

Interventions for the management of temporomandibular joint osteoarthritis (2011)[Cochrane]

New evidence for naproxen/esomeprazole combination in knee osteoarthritis (2011) [NPC Rapid Review]

Oral calcitonin - Osteoarthritis of knee (2010)[NHSC]

Interventions for treating osteoarthritis of the big toe joint (2010) [Cochrane]

Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study) (2010)[NIHR HTA]

Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis (2010)[DARE]

Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis (2010)[DARE]

Individually magnetic resonance imaging-designed unicompartmental interpositional implant insertion for osteoarthritis of the knee (2009)[NICE]

Surgery for shoulder osteoarthritis (2009) [Cochrane]

Joint lavage for osteoarthritis of the knee (2009)[Cochrane]

Therapeutic ultrasound for osteoarthritis of the knee or hip (2009)[Cochrane]

Oral or transdermal opioids for osteoarthritis of the knee or hip (2009) [Cochrane][Cochrane PEARLS]

Doxycycline for osteoarthritis of the knee or hip (2009) [Cochrane]

Exercise for osteoarthritis of the hip (2009) [Cochrane]

Surgery for thumb (trapeziometacarpal joint) osteoarthritis (2009) [Cochrane]

Glucosamine therapy for treating osteoarthritis (2009) [Cochrane]

Transcutaneous electrostimulation for osteoarthritis of the knee (2009) [Cochrane]

Three Treatments for Osteoarthritis of the Knee: Clinician's guide (2009)[AHRQ]

The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation (2009) [NIHR HTA]

Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation
(2009)[NIHR HTA][DARE]

Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part 1: Osteoarthritis (2009)[DARE]

A systematic review of ultrasonography in osteoarthritis (2009)[DARE]

S-Adenosylmethionine for osteoarthritis of the knee or hip (2008) [Cochrane]

Acupuncture for peripheral joint osteoarthritis (2008)[Cochrane] [Cochrane PEARLS]

Exercise for osteoarthritis of the knee (2008)[Cochrane]

Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis (2008)[DARE]

Unicompartmental knee arthroplasty for the treatment of unicompartmental osteoarthritis: a systematic study (2008)[DARE]

Arthroscopic debridement for knee osteoarthritis (2007)[Cochrane]

Osteoarthritis of the knee (2007)[Clinical Evidence]

Osteoarthritis of the hip (2007)[Clinical Evidence]



Clinical Guidelines

Osteoarthritis :Care and management in adults (2014)[NICE] updated

Osteoarthritis (2013) [CKS] updated

Osteoarthritis (2013)[Map of Medicine] updated

OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009 (2010)[OARSI]*

OARSI recommendations for the management of hip and knee osteoarthritis Part II - OARSI evidence-based expert consensus guidelines (2008)[OARSI]*

* OARSI recommendations to be updated in 2014 also.


Recent articles in core journals


A systematic review of evidence for the effectiveness of practitioner-based complementary and alternative therapies in the management of rheumatic diseases: osteoarthritis (2013)[Rheumatology] NEW

90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis (2013)[Lancet] NEW

Ottawa panel evidence-based clinical practice guidelines for aerobic walking programs in the management of osteoarthritis (2012)[Arch Phys Med Rehabilitation] NEW

Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial (2009)[Arthritis Rheum]

Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies (2009) [BMJ]


eTextbooks

Osteoarthritis (2010)[Mentor]


Clinical Queries

Is there any evidence for the use of rosehip powder for osteoarthritis? (2008)[ATTRACT]



Patient Information

Osteoarthritis (2014)[BUPA] updated

Osteoarthritis (2012)[NHS Choices]  updated

Osteoarthritis (2012)[Patient UK] updated





Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Statins

Evidence Based Reports

 

Comparative Effectiveness Review, Combination Therapy Versus Intensification of Statin Monotherapy: An Update (2013)[AHRQ] NEW

 

Ezetimibe (Ezetrol) in combination with a statin for reduction of cardiovascular risk in coronary heart disease (2013) [National Horizon Scanning Centre] NEW

Statins and cognitive function: a systematic review (2013) [DARE] NEW

Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery (2012)[Cochrane] NEW

Statins for the primary prevention of cardiovascular disease (2012)[Cochrane] updated

HMG CoA reductase inhibitors (statins) for kidney transplant recipients (2012)[Cochrane] updated
 
Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis (2012)[DARE] NEW

Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations (2012)[DARE] NEW

Statin therapy and the risk of intracerebral hemorrhage: a meta-analysis of 31 randomized controlled trials (2012)[DARE] NEW

Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis (2012)[DARE] NEW

Statins for age-related macular degeneration (2011) [Cochrane] updated

Statins for women with polycystic ovary syndrome not actively trying to conceive (2011)[Cochrane]

Statins for multiple sclerosis (2011) [Cochrane]

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials (2011)[DARE] NEW

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials (2011)[DARE] NEW

Statins and prevention of infections: systematic review and meta-analysis of data from large randomised placebo controlled trials (2011)[DARE] NEW

Statins for children with familial hypercholesterolemia (2010)[Cochrane]

Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65229 participants (2010)[DARE]

Effect of statins pretreatment on periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention: a meta-analysis (2010)[DARE]

Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis (2010)[DARE]

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis (2008)[Cochrane]

Statins for the prevention of dementia (2008)[Cochrane]

Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review (2009)[DARE]

Statin therapy and risk of developing type 2 diabetes: a meta-analysis (2009) [DARE]

Statins for the prevention and treatment of infections: a systematic review and meta-analysis (2009)[DARE]

The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials (2009)[DARE]

Statins for secondary prevention in elderly patients: a hierarchical Bayesian meta-analysis (2008)[DARE]

Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials (2008)[DARE]

The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials (2008)[DARE]

Statins and cancer: a meta-analysis of case-control studies (2008)[DARE]

Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients (2008)[DARE]

Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30 000 patients (2008)[DARE]

Statins for infection and sepsis: a systematic review of the clinical evidence (2008)[DARE]

Statin use and development of atrial fibrillation: a systematic review and meta-analysis of randomized clinical trials and observational studies (2008)[DARE]


Clinical Guidelines

Lipid modification - primary and secondary CVD prevention (2008)[CKS]

Lipid modification (2008)[NICE]


Recent articles in core journals

Statin use and reduced cancer-related mortality (2012)[NEJM]

Effect of two intensive statin regimens on progression of coronary disease (2011) [NEJM]

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. (2011) [NEJM]

Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. (2011)[JAMA]

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials (2010)[Lancet]

Meta-analysis: Statin Therapy Does Not Alter the Association Between Low Levels of High-Density Lipoprotein Cholesterol and Increased Cardiovascular Risk (2010)[Annals of Internal Medicine]

Statin use and the prevention of venous thromboembolism: a meta-analysis (2010)[Int J Clin Pract]


eTextbooks

Statins (2010)[GP Notebook]


Clinical Queries

Does the use of statins for primary prevention reduce mortality from CVD in patients >80 years? (2013)[ATTRACT] NEW

What is the most recent evidence regarding whether statins can cause memory loss or dementia? (last search 2005)Is there any evidence that statins help patients establish dementia particularly vascular dementia? (2012)[ATTRACT] NEW

Which statin is safest in renal failure? (2011) [TRIPanswers]

What is the current guidance on statin treatment for primary prevention in patients with calculated 10-yr CVD risk < 20% but Total cholesterol/HDL ratio > 6.0? (2010)[ATTRACT]


Patient Information


Statins (2013)[BUPA Health Information] NEW

Cholesterol-lowering medicines, statins (2012)[NHS Choices]

Statins and Other Lipid Lowering Drugs (2011)[Patient UK]







Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.Statins for the treatment of dementia (2009)[Cochrane]

Chlamydia

Evidence Based Reports


Chlamydia (uncomplicated, genital) (2009)[Clinical Evidence] Log-in required

Systematic review of the clinical effectiveness and cost-effectiveness of rapid point-of-care tests for the detection of genital chlamydia infection in women and men (2010)[NIHR HTA]

Testing for Chlamydia trachomatis in Primary Care using self-taken swabs (2009)[MaDOx]


Clinical Guidelines

Re-testing of young persons diagnosed with chlamydia infection (2013)[BASHH] NEW

Chlamydia (2011)[Map of Medicine]

Chlamydia trachomatis: UK Testing Guidelines (2010)[BASHH]

Chlamydia - uncomplicated genital (2009)[CKS]

Management of genital Chlamydia trachomatis infection (2009)[SIGN]

BASHH CEG statement on Chlamydia window period (2008)[BASHH]



Recent articles in core journals

Assessment of best single sample for finding chlamydia in women with and without symptoms: a diagnostic test study (2012)[BMJ] NEW

Costs and cost effectiveness of different strategies for chlamydia screening and partner notification: an economic and mathematical modelling study(2011)[BMJ]

Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial (2010)[BMJ]

Expedited partner therapy for Chlamydia trachomatis at the community pharmacy (2010)[NELM]



eTextbooks

Chlamydial Genital Infection (2013)[Mentor] updated

Chlamydia test (2012) [Lab tests online] NEW

Chlamydia infection: diagnosis and management Interactive case history (2007)[BMJ Learning]



Clinical Queries

Are self-taken vulvo-vaginal swabs more sensitive than endocervical swabs for chlamydia and gonorrhoea testing by nucleic acid amplification tests (NAAT) prior to IUD insertion? (2013)[FSRH] NEW

What is the probability/likelihood of being infertile from an episode of chlamydia PID?(2013) [ATTRACT] NEW




Patient Information


Chlamydia (2013)[NHS Choices] updated

Chlamydia (2011) [BUPA]






Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Schizophrenia

Evidence Based Reports

Aripiprazole versus other atypical antipsychotics for schizophrenia(2014)[Cochrane] updated

ESNM15 Schizophrenia: lurasidone (2013) [NICE] NEW

Fluphenazine (oral) versus placebo for schizophrenia (2013) [Cochrane] NEW

Effect of psychosocial interventions on social functioning in depression and schizophrenia: meta-analysis (2013)[DARE]  NEW

Intermittent drug techniques for schizophrenia (2013)[Cochrane]  NEW

Group art therapy as an adjunctive treatment for people with schizophrenia: a randomised controlled trial (MATISSE) (2012) [NIHR HTA] NEW

Oral versus depot antipsychotic drugs for schizophrenia: a critical systematic review and meta-analysis of randomised long-term trials (2012) [DARE]NEW

Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses (2012)[Cochrane] NEW

Maintenance treatment with antipsychotic drugs for schizophrenia (2012)[Cochrane]NEW

Chlorpromazine dose for people with schizophrenia (2012)[Cochrane] updated

Dance therapy for schizophrenia (2012)[Cochrane] updated

Paliperidone palmitate (Xeplion)- for the maintenance treatment of schizophrenia (2012) [AWMSG] updated

Bromperidol decanoate (depot) for schizophrenia (2012)[Cochrane] updated

Acetylcholinesterase inhibitors for schizophrenia (2011) [Cochrane]

Music therapy for people with schizophrenia and schizophrenia-like disorders (2011)[Cochrane]

Antipsychotic drug treatment for elderly people with late-onset schizophrenia (2011)[Cochrane]

Psychoeducation for schizophrenia (2011)[Cochrane]

Aripiprazole for schizophrenia in people aged 15 to 17 years (2011) [NICE]

Schizophrenia (2010) [BMJ Clinical Evidence] updated Log in required

Aripiprazole versus placebo for schizophrenia (2010)[Cochrane]

Quetiapine versus other atypical antipsychotics for schizophrenia (2010)[Cochrane]

Zotepine versus other atypical antipsychotics for schizophrenia (2010)[Cochrane]

Beta-blocker supplementation of standard drug treatment for schizophrenia (2010)[Cochrane]

Asenapine (Sycrest) Schizophrenia - acute and maintenance, first or second line (2010)[NHSC]

Loxapine inhalation (Staccato Loxapine) - Agitation associated with schizophrenia or bipolar-1 disorder (2010)[NHSC]

Sulpiride augmentation for schizophrenia (2009)[Cochrane]

Antipsychotic medication for early episode schizophrenia (2009)[Cochrane]

Levomepromazine for schizophrenia (2009)[Cochrane]

Exercise therapy for schizophrenia (2009)[Cochrane]

Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness (2009)[Cochrane]

Monetary incentives for schizophrenia (2009)[Cochrane]

Sulpiride versus placebo for schizophrenia (2009)[Cochrane]

Polyunsaturated fatty acid supplementation for schizophrenia (2009)[Cochrane]

Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness (2009)[Cochrane]

Day hospital versus outpatient care for people with schizophrenia (2009)[Cochrane]

Clozapine versus typical neuroleptic medication for schizophrenia (2009)[Cochrane]

Antipsychotic switching for people with schizophrenia who have neuroleptic-induced weight or metabolic problems (2008)[Cochrane]

Risperidone versus placebo for schizophrenia (2008)[Cochrane]

Risperidone dose for schizophrenia (2008)[Cochrane]

Risperidone versus other atypical antipsychotics for schizophrenia (2008)[Cochrane]

Clozapine versus other atypical antipsychotics for schizophrenia (2008)[Cochrane]

Clozapine combined with different antipsychotic drugs for treatment resistant schizophrenia (2008)[Cochrane]

Benzodiazepines for catatonia in people with schizophrenia and other serious mental illnesses (2008)[Cochrane]

Twenty-four hour care for schizophrenia (2008)[Cochrane]

Aripiprazole versus typical antipsychotic drugs for schizophrenia (2008)[Cochrane]

Aripiprazole (Abilify) Schizophrenia in children (2008)[NHSC]

Oral paliperidone for schizophrenia (2008)[Cochrane]

Morita therapy for schizophrenia (2008)[Cochrane]

Valproate for schizophrenia (2008)[Cochrane]

Olanzapine versus other atypical antipsychotics for schizophrenia (2007)[Cochrane]

Amisulpride versus other atypical antipsychotics for schizophrenia (2007)[Cochrane]

Ziprasidone versus other atypical antipsychotics for schizophrenia (2007)[Cochrane]

Sertindole versus other atypical antipsychotics for schizophrenia (2007)[Cochrane]

Atypical antipsychotics for people with both schizophrenia and depression (2007)[Cochrane]

Cannabis and schizophrenia (2007)[Cochrane]

Haloperidol versus chlorpromazine for schizophrenia (2007)[Cochrane]


Clinical Guidelines


Psychosis and schizophrenia in adults: treatment and management (2014) [NICE] NEW

Psychosis and schizophrenia in children and young people: Recognition and management (2013)[NICE] NEW

Management of Schizophrenia (2013)[SIGN] NEW

Schizophrenia (2013) [Map of Medicine] updated
Core interventions in the treatment and management of schizophrenia in primary and secondary care (update) (2009) [NICE]

Schizophrenia (2009)[CKS]



Recent articles in core journals

Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia (2013) [JAMA Psychiatry] NEW

Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic (2011)[Int J Clin Pract]

Acupuncture for schizophrenia: a systematic review and meta-analysis (2009)[Int J Clin Pract]


eTextbooks

Schizophrenia (2014)[eMedicine] updated

Schizophrenia (2013)[Mentor]



Clinical Queries

What is the best practice (and/or guidance) on the treatment for patients suffering depression and schizophrenia? (2008) [TRIPAnswers]


Patient Information

Schizophrenia (2014)[Royal College of Psychiatrists] updated

Schizophrenia (2012)[BUPA] updated

Schizophrenia (2012) [NHS Choices] updated




Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Bell's Palsy

Evidence Based Reports

Hyperbaric oxygen therapy for Bell's palsy (2012)[Cochrane] NEW

Physical therapy for Bell´s palsy (idiopathic facial paralysis)(2011)[Cochrane]

Bell's Palsy (2010) [Clinical Evidence] Athens Log-in required

Acupuncture for Bell's palsy (2010) [Cochrane]

Antivirals for Bell's Palsy (2010)[theNNT]

Steroids for Bell's Palsy (2010)[theNNT]

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study (2009)[NCCHTA]

Antiviral treatment for Bell's palsy (idiopathic facial paralysis) (2009)[Cochrane]

The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis (2009)[DARE]

Combined corticosteroid and antiviral treatment for bell palsy: a systematic review and meta-analysis (2009)[DARE]

Corticosteroids for Bell's palsy (idiopathic facial paralysis) (2008) [Cochrane]

Do we need to give steroids in children with bell's palsy? (2005) [BestBETS]


Clinical Guidelines

Bell's Palsy (2012)[CKS] updated


Recent articles in core journals

Steroid-antiviral treatment improves the recovery rate in patients with severe Bell's palsy (2013) [Am J Med] NEW

The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis (2009) [BMJ]

Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis (2009)[JAMA]

Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell`s palsy (2009) [EvidenceUpdates]

Bell's palsy: diagnosis and management (2007) [Am Fam Physician]

Bell's palsy: a review of treatment using antiviral agents (2006) [Ann Pharmacotherapy]

Managing Bell's palsy (2006) [Drug Ther Bull]


eTextbooks

Bell's palsy: diagnosis and treatment (2010) [BMJ Learning]


Clinical Queries

What are the chances of a patient presenting in the UK with Ball’s Palsy having Lyme disease? Should anyone presenting with Bell’s Palsy have serology for Lyme disease (2010) [ATTRACT]

Is there any evidence of any therapy to improve a residual facial weakness following Bell's palsy in a 45 yr old woman who was treated with steroids and aciclovir on presentation 6 months ago? (2009) [ATTRACT]


Patient Information

Bell's palsy (2012)[NHS Choices] updated

Bell's Palsy (2012) [BUPA Health Information] updated


Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Vasectomy

Evidence Based Reports

Scalpel versus no-scalpel incision for vasectomy (2011)[Cochrane]

Vasectomy occlusion techniques for male sterilization (2011)[Cochrane]


Clinical Guidelines

Vasectomy (2013)[Map of Medicine] updated

European Association of Urology Guidelines on Vasectomy (2011)[European Association of Urology]


Recent articles in core journals

Vasectomy reversal outcomes among patients with vasal obstructive intervals greater than 10 years (2014) [Urology] NEW

Vasectomy: the other (better) form of sterilization(2011)[Contraception]

Mini-Incision Vasectomy Reversal Using No-scalpel Vasectomy Principles: Efficacy and Postoperative Pain Compared With Traditional Approaches to Vasectomy Reversal (2011)[Urology]

Vasectomy reversal (2008)[Fertility and Sterility]

Vasectomy and the Risk of Prostate Cancer (2008)[Journal of Urology]


eTextbooks

No Scalpel Vasectomy (2013)[eMedicine] updated

Sterilisation (Female Sterilisation and Vasectomy)(2012)[Mentor]

Vasectomy - a guide for GPs (2011)[BMJ Learning]


Clinical Queries

Is there any increase risk of testicular or prostate cancer following vasectomy? (2009) [TRIPAnswers]

What are the causes and treatment of post-vasectomy pain? What are the other common complications after vasectomy (apart from bleeding)? (2008)[TRIPAnswers]



Patient Information

Vasectomy (2013)[NHS Choices] updated

Vasectomy (2012)[BUPA Health Information] updated

Vasectomy reversal (2012)[BUPA Health Information] updated



Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Autism

Evidence Based Reports

Evidence update: Recognition, referral and diagnosis of children and young people on the autism spectrum (2013)[NICE] NEW

Screening and Diagnostic Tools for Autism Spectrum Disorder in Children: A Review of Guidelines (2013) [CADTH] NEW

 

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)(2013)[Cochrane] updated

Comparative Effectiveness Review: Interventions forAdolescents and YoungAdults With AutismSpectrum Disorders (2012) [AHRQ] [Summary document] NEW

Potential High-Impact Interventions for Developmental Delays, ADHD, and Autism (2012) [AHRQ Horizon Scanning] NEW

Managing the Eating Habits of Autistic Children who are Resistant Eaters: Clinical Effectiveness and Guidelines  (2012) [CADTH] NEW

 

Social skills groups for people aged 6 to 21 with autism spectrum disorders (ASD) (2012) [Cochrane] NEW

Tricyclic antidepressants for autism spectrum disorders (ASD) in children and adolescents (2011)[Cochrane]

Aripiprazole for autism spectrum disorders (ASD)(2011)[Cochrane]

Acupuncture for autism spectrum disorders (ASD)(2011)[Cochrane]

Auditory integration training and other sound therapies for autism spectrum disorders (ASD)(2011)[Cochrane]

Intravenous secretin for autism spectrum disorders (ASD)(2010)[Cochrane]

Omega-3 fatty acids supplementation for autism spectrum disorders (ASD)(2010)[Cochrane]

Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review (2010)[DARE]

Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (2010)[QIPP]

Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model (2010)[DARE]

Autism (2009)[Clinical Evidence] Log-in required

The use of weighted vests with children with autism spectrum disorders and other disabilities (2009)[DARE]

Gluten- and casein-free diets for autistic spectrum disorder (2007)[Cochrane]

Parent implemented early intervention for young children with autism spectrum disorder: a systematic review (2008)[DARE]


Clinical Guidelines

The management and support of children and young people on the autism spectrum (2013)[NICE]NEW

Autism: Recognition, referral and diagnosis of children and young people on the autism spectrum (2012)[NICE] NEW

Autism in children and young people: Pathway (2014)[NICE] updated

Assessment, diagnosis and clinical interventions for children and young people with autism spectrum disorders (2007)[SIGN]


Recent articles in core journals

Cognitive-behavioral therapy for anxiety in children with high-functioning autism: a meta-analysis (2013)[Pediatrics] NEW

A systematic review of medical treatments for children with autism spectrum disorders (2011)[Pediatrics]

Mitochondrial dysfunction in autism (2010)[JAMA]

Autism (2009)[Lancet]

Prenatal risk factors for autism: comprehensive meta-analysis (2009)[Br J Psychiatry]



eTextbooks

Autism (2014)[Medscape Reference] updated

Autism (2011)[Mentor]

Autism: diagnosis in primary care (2007)[BMJ Learning]



Clinical Queries

What is the best way of picking up autism in pre-school children? (2009)[CLEAR- NHS Scotland]



Patient Information

Autism and Asperger syndrome (2013)[NHS Choices] updated

Autism (2013)[MedlinePlus] updated

The National Autistic Society


Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Bipolar Disorder

Evidence Based Reports

 

Aripiprazole for treating moderate to severe manic episodes in adolescents with bipolar I disorder (2013)[NICE] NEW
 

Tiagabine in the maintenance treatment of bipolar disorder (2012) [Cochrane] updated

Second generation antipsychotics in the treatment of bipolar depression: a systematic review and meta-analysis (2012)[DARE] NEW

Efficacy and safety of electroconvulsive therapy in the treatment of bipolar disorder: a systematic review (2011)[
DARE] NEW

Oxcarbazepine for acute affective episodes in bipolar disorder (2011) [Cochrane]

Sodium Valproate (Episenta) - for the treatment of manic episode in bipola disorder (2011)[AWMSG]

Efficacy and safety of electroconvulsive therapy in the treatment of bipolar disorder: a systematic review (2011)[DARE]

Asenapine (Saphris) for manic episodes associated with bipolar 1 disorder (2010) [National Horizon Scanning Centre]

Tolerability of atypical antipsychotics in the treatment of adults with schizophrenia or bipolar disorder: a mixed treatment comparison of randomized controlled trials (2010)[DARE]

Comparison of carbamazepine and lithium in treatment of bipolar disorder: a systematic review of randomized controlled trials (2010)[DARE]

Risperidone (Risperdal Consta) injection - Bipolar 1 disorder – prevention of recurrent mania (2009)[National Horizon Scanning Centre]

Aripiprazole (Abilify) Bipolar I disorder in children, acute mania (2009)[National Horizon Scanning Centre]

Omega-3 fatty acids for bipolar disorder (2008)[Cochrane]

Olanzapine in long-term treatment for bipolar disorder (2007)[Cochrane][Cochrane PEARLS]

Oxcarbazepine in the maintenance treatment of bipolar disorder (2007) [Cochrane]

Bipolar Disorder (2006)[Clinical Evidence] Log-in required



Clinical Guidelines

Bipolar Disorder (2014)[Map of Medicine] updated
Bipolar Disorder (2009)[CKS]

Evidence-based guidelines for treating bipolar disorder: revised second edition - recommendations from the British Association for Psychopharmacology (2009)[BAP]

The management of bipolar disorder in adults, children and adolescents, in primary and secondary care (2006)[NICE]



Recent articles in core journals

Bipolar disorder diagnosis: challenges and future directions (2013) [Lancet] NEW

Treatment of bipolar disorder (2013) [Lancet] NEW
Strategies for the early recognition of bipolar disorder (2011)[J Clin Psychiatry]

Detection of bipolar disorder (2011)[Br J Pscyhiatry]

Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review (2010)[Br J Psychiatry]

Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome (2008)[Arch Gen Psychiatry]


eTextbooks

Bipolar Disorder (2012)[Mentor]

Bipolar disorder: management in primary care - in association with NICE (2011)[BMJ Learning]



Clinical Queries

For a patient who is taking lithium for bipolar disorder are there any restrictions with regards to choice of hormonal contraception?(2011)[FSRH]

How should a patient taking lithium for bipolar disorder with serum creatinine levels outside the normal range and a gradually decreasing eGFR be managed? (2008)[TRIPAnswers]



Patient Information

Bipolar disorder (2012)[NHS Choices]NEW

Bipolar Affective Disorder (2012) [BUPA] NEW

Bipolar Disorder (manic depression)(2012)[RCPsych] updated
Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

Psoriasis

Evidence Based Reports

Apremilast for psoriasis (2013) [ National Horizon Scanning Centre] NEW

Dimethyl fumarate for plaque psoriasis (2013) [National Horizon Scanning Centre] NEW

Ustekinumab (Stelara) for plaque psoriasis in adolescents (2013) [National Horizon Scanning Centre] NEW

Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis (2012) [AHRQ] [Summary document] NEW

Tofacitinib for moderate to severe chronic plaque psoriasis – second line (2012) [National Horizon Scanning Centre] NEW

Secukinumab for plaque psoriasis (2012) [National Horizon Scanning Centre] NEW

Infliximab versus Methotrexate, Etanercept, Adalimumab, and Ustekinumab for Plaque Psoriasis: A Review of the Comparative Clinical Efficacy, Safety and Cost Effectiveness (2012)[CADTH] NEW

Efficacy of biologics in the treatment of moderate to severe psoriasis: a network meta-analysis of randomized controlled trials (2012)[DARE] NEW

Association between biologic therapies for chronic plaque psoriasis and cardiovascular events: a meta-analysis of randomized controlled trials (2011) [DARE]

Ustekinumab for the treatment of adults with moderate to severe psoriasis (2009)[NICE]

Etanercept and efalizumab for the treatment of adults with psoriasis (2006)[NICE]

Topical treatments for chronic plaque psoriasis (2011)[Cochrane] updated

Infliximab for the treatment of adults with psoriasis (2008)[NICE]

Adalimumab for the treatment of adults with psoriasis (2008)[NICE]

Safety and efficacy of alefacept, efalizumab, etanercept and infliximab in treating moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials (2008)[DARE]

Psoriasis (chronic plaque)(2007)[Clinical Evidence]


Clinical Guidelines
 

Psoriasis:The assessment and management of psoriasis (2012)[NICE] NEW

Psoriasis(2012)[CKS] updated

Diagnosis and management of psoriasis and psoriatic arthritis in adults(2010)[SIGN]

British Association of Dermatologists’ guidelines for biologic interventions for psoriasis (2009)[British Association of Dermatologists]



Recent articles in core journals

Effective and sustainable biologic treatment of psoriasis: what can we learn from new clinical data? (2012) [J Eur Acad Dermatol Venereol] NEW

Adherence to topical treatment in psoriasis: a systematic literature review (2012) [J Eur Acad Dermatol Venereol] NEW

Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis (2012) [NEJM]NEW

Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis (2012)[NEJM]NEW

A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis (2011)[NEJM]

Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trial (2010)[BMJ]

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis (2010)[NEJM]

Efficacy and safety of combination Acitretin and Pioglitazone therapy in patients with moderate to severe chronic plaque-type psoriasis: a randomized, double-blind, placebo-controlled clinical trial (2009)[Arch Dermatol]

Incidence and clinical predictors of psoriatic arthritis in patients with psoriasis: a population-based study(2009)[Arthritis Rheum]

A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trial (2008)[J Am Acad Dermatol]

Etanercept treatment for children and adolescents with plaque psoriasis (2008)[NEJM]


eTextbooks

Psoriasis (2014)[eMedicine] updated

Plaque Psoriasis (2013)[eMedicine] updated

Psoriasis, Pustular (2013)[eMedicine] updated

Psoriasis of Hands and Feet (2013)[Mentor] updated

Chronic Plaque Psoriasis (2012)[Mentor] updated

Guttate Psoriasis (2011)[Mentor]

Generalised Pustular Psoriasis (2011)[Mentor]

Erythrodermic Psoriasis (2011)[Mentor]


Clinical Queries

What is evidence for use of low dose naltrexone in psoriasis.? It would be unlicenced use - what information would I need to share with patient and can I prescribe on nhs? (2012) [ATTRACT] NEW

Cigarette smoking is known to reduce the symptoms and severity of psoriasis. Can nicotine replacement therapy have similar benefits? (2012)[ATTRACT]NEW

What is the evidence for neem oil in scalp psoriasis? (2010)[ATTRACT]

Is there any evidence that propranolol makes psoriasis worse? (2008)[ATTRACT]



Patient Information

Treatments for Moderate or Severe Psoriasis (2013)[British Association of Dermatologists] updated

Topical Treatments for Psoriasis (2013)[British Association of Dermatologists] updated

Psoriasis (2013)[NHS Choices] updated

Psoriasis – an Overview (2012)[British Association of Dermatologists] updated

Psoriasis (2012)[Patient UK] updated

Coal Tar for Psoriasis (2012)[Patient UK] updated

Vitamin D Analogues for Psoriasis (2012)[Patient UK] updated

Psoriasis (2012)[BUPA] updated





Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.