Tuesday, 8 April 2014


Evidence Based Reports

Lithium or an atypical antipsychotic drug in the management of treatment-resistant depression: a systematic review and economic evaluation. (2013) [HTA] NEW

A cluster randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of classroom-based cognitive–behavioural therapy (CBT) in reducing symptoms of depression in high-risk adolescents. (2013) [HTA] NEW

The effects of qigong on anxiety, depression, and psychological well-being: a systematic review and meta-analysis. (2013) [DARE] NEW

Influence of initial severity of depression on effectiveness of low intensity interventions: meta-analysis of individual patient data. (2013) [DARE] NEW

Second generation antipsychotics in the treatment of bipolar depression: a systematic review and meta-analysis. (2013) [DARE] NEW

Smoking cessation interventions for smokers with current or past depression. (2013) [Cochrane Library] NEW

Tricyclic drugs for depression in children and adolescents. (2013) [Cochrane Library] NEW

Walking for depression or depressive symptoms: a systematic review and meta-analysis. (2012) [DARE] NEW

Fluoxetine versus other types of pharmacotherapy for depression. (2012) [Cochrane Library] NEW

Alprazolam for depression. (2012) [Cochrane Library] NEW

Citalopram versus other anti-depressive agents for depression. (2012) [Cochrane Library] NEW

Psychological and pharmacological interventions for depression in patients with coronary artery disease (2011) [Cochrane Library]

Pharmacologic treatment of depression in multiple sclerosis (2011) [
Cochrane Library]

Mirtazapine versus other antidepressive agents for depression (2011) [
Cochrane Library]

Psychological and educational interventions for preventing depression in children and adolescents (2011) [
Cochrane Library]

Active placebos versus antidepressants for depression (2011) [
Cochrane Library]

Second-generation antipsychotics for major depressive disorder and dysthymia (2010)[

Fluvoxamine versus other anti-depressive agents for depression (2010)[

Antidepressants for depression in physically ill people (2010)[

Telemedicine for depression: a systematic review (2010)[

Effects of befriending on depressive symptoms and distress: systematic review and meta-analysis (2010)[

Milnacipran versus other antidepressive agents for depression (2009)[

Antidepressants versus placebo for depression in primary care (2009)[

Sertraline versus other antidepressive agents for depression (2009)[

Efficacy, tolerability and side-effect profile of fluvoxamine for major depression: meta-analysis (2009)[

Psychological treatment of depression in primary care: a meta-analysis (2009)[

Vagus nerve stimulation for treatment-resistant depression (2009)[

Clinical Guidelines

Depression. (2013) [CKS] NEW

Depression in children. (2013) [CKS] NEW

Depression overview (2011) [
NICE Pathways]

Non-pharmaceutical management of depression in adults (2010)[

Depression The treatment and management of depression in adults (2009)[

Depression in adults with a chronic physical health problem (2009)[

Recent articles in core journals

Screening for depression in Parkinson's disease: the performance of two screening questions. (2013) [EvidenceUpdates] NEW

Prevention of depression in at-risk adolescents: longer-term effects. (2013) [EvidenceUpdates] NEW

Clinical effectiveness of collaborative care for depression in UK primary care (CADET): cluster randomised controlled trial. (2013) [BMJ] NEW

Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial. (2013) [EvidenceUpdates] NEW

A structural multidisciplinary approach to depression management in nursing-home residents: a multicentre, stepped-wedge cluster-randomised trial. (2013) [Lancet] NEW

Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial. (2013) [Lancet] NEW

Effects of music on depression in older people: a randomised controlled trial. (2012) [EvidenceUpdates] NEW

Depression in adolescence. (2012) [Lancet] NEW

Major depressive disorder: new clinical, neurobiological, and treatment perspectives. (2011) [

Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis. (2011) [Ann Intern Med]

Randomized controlled trial of brief cognitive behavioral intervention for depression and anxiety symptoms preoperatively in patients undergoing coronary artery bypass graft surgery. (2011) [EvidenceUpdates]

Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. (2010)[

Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. (2010)[

In the clinic. Depression. (2010)[
Annals of Internal Medicine]

Effects of befriending on depressive symptoms and distress: systematic review and meta-analysis. (2010)[

Personality change during depression treatment: a placebo-controlled trial. (2010)[

Antidepressant drug effects and depression severity: a patient-level meta-analysis. (2010)[

Management of depression in UK general practice in relation to scores on depression severity questionnaires: analysis of medical record data. (2009)[

Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. (2009)[

Long-term benefits of short-term quality improvement interventions for depressed youths in primary care. (2009)[

Screening for depression in adult patients in primary care settings: a systematic evidence review. (2009)[
Annals of Internal Medicine]

Therapist-delivered Internet psychotherapy for depression in primary care: a randomised controlled trial. (2009)[


Depression in Children and Adolescents (2013)[
Mentor] updated

Screening for Depression in Primary Care (2011)[

referral criteria from primary care - depression (2008)[

depression in old age (2008)[

secondary depression (2008)[

major depression (2008)[

recurrent depressive disorder (2008)[

Clinical Queries

Which would be the antidepressant of choice/prescribing guidelines for a patient that has depression predominantly around her menstruation? I recall there is a medication that we can just prescribe for 1 week a month. (2013) [ATTRACT] NEW

What basic tools can be used by any health care professional in primary care for screening of patients with long-term conditions for mental health symptoms (anxiety and depression)? (2012) [ATTRACT] NEW

Is there evidence to suggest that copper-bearing IUDs (Cu-IUD) are associated with depression / anxiety post insertion? (2012) [FRSH] NEW

For a patient who is taking lithium for bipolar disorder are there any restrictions with regards to choice of hormonal contraception? (2011) [

What are the issues with longterm (10-20yrs +) treatment of depression with dosulepin 75mg daily? (2011) [

With hospitalised patients over age 80 with newly diagnosed depression, is pharmacotherapy with antidepressants superior to placebo in improving depressive symptoms? (2009)[

What is the most recent evidence with regards St Johns Wort in the treatment of depression?(2009)[

Is there any evidence to support the use of 5-HTP in the treatment of anxiety and depression? Are there any known contraindications to its use? (2008)[

Can fish oil help reduce depression and/or first episode psychosis? (Q & A provided by Evidence Direct via the Centre for Evidence Based Practice Australasia)(2008)[

Are there any national self-help groups for patients with depression? (2008)[

Patient Information

Depression (2013) [RCPsych] updated

Depression in Older Adults (20130 [RCPsych] updated

Alcohol and Depression (2013)[RCPsych] updated

Clinical depression (2012)[
NHS Choices]

Depression (2012)[


1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.

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