COPD

Evidence Based Reports

The effect of complex interventions on depression and anxiety in chronic obstructive pulmonary disease: systematic review and meta-analysis. (20130 [DARE] NEW

Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis. (2013) [DARE] NEW

Does upper extremity exercise improve dyspnea in patients with COPD? A meta-analysis. (2013) [DARE] NEW

Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: systematic review and mixed treatment comparison meta-analysis of randomised controlled trials. (2013) [DARE] NEW

Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review. (2012) [DARE] NEW

Home care by outreach nursing for chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Nocturnal non-invasive positive pressure ventilation for stable chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Telehealthcare for chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Airway clearance techniques for chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

Long-acting beta2-agonist in addition to tiotropium versus either tiotropium or long-acting beta2-agonist alone for chronic obstructive pulmonary disease. (2012) [Cochrane Library] NEW

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta2-agonists for chronic obstructive pulmonary disease (2011)[Cochrane]

Combination inhaled steroid and long-acting beta2-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease (2011)[Cochrane]

Pharmacological interventions for the treatment of anxiety disorders in chronic obstructive pulmonary disease (2011) [Cochrane]

Optimal intensity and type of leg exercise training for people with chronic obstructive pulmonary disease (2011) [Cochrane]

Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease (2011)[Cochrane]

Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease (2010)[Cochrane]

Influenza vaccine for patients with chronic obstructive pulmonary disease (2010)[Cochrane]

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease (2010)[Cochrane]

Action plans with limited patient education only for exacerbations of chronic obstructive pulmonary disease (2010)[Cochrane]

Smoking cessation interventions in COPD: a network meta-analysis of randomised trials (2010)[DARE]

Inspiratory muscle training in patients with chronic obstructive pulmonary disease: the state of the evidence (2010)[DARE]

Bronchoscopic lung volume reduction with airway valves for advanced emphysema (2009)[NICE]

Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease (2009)[Cochrane]

Screening for chronic obstructive pulmonary disease using spirometry: summary of the evidence for the U.S. preventive services task force (2009)[DARE]

Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies (2009)[DARE]

Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis (2009)[DARE]

Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis (2009)[DARE]

Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis (2009) [DARE]

Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis (2009) [DARE]

Oxygen therapy in the pre-hospital setting for acute exacerbations of chronic obstructive pulmonary disease (2009) [Cochrane]

Oxygen therapy during exercise training in chronic obstructive pulmonary disease (2009) [Cochrane]

Clinical Guidelines

COPD (2013)[NICE Pathways] updated

Management of chronic obstructive pulmonary disease in adults in primary and secondary care (partial update)(2010)[NICE]

Chronic obstructive pulmonary disease (2010)[CKS]

Chronic obstructive pulmonary disease: Management of chronic obstructive pulmonary disease in adults in primary and secondary care (2004) [NICE]

Recent articles in core journals

Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation history. (2011)[EvidenceUpdates]

Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. (2011)[EvidenceUpdates]

Changes in forced expiratory volume in 1 second over time in COPD. (2011)[NEJM]

The future of chronic obstructive pulmonary disease treatment--difficulties of and barriers to drug development. (2011)[Lancet]

Azithromycin for prevention of exacerbations of COPD. (2011)[NEJM]

Tiotropium versus salmeterol for the prevention of exacerbations of COPD. (2011)[NEJM]

Ground walk training improves functional exercise capacity more than cycle training in people with chronic obstructive pulmonary disease (COPD): a randomised trial (2010)[EvidenceUpdates]

Disease management program for chronic obstructive pulmonary disease: a randomized controlled trial (2010)[EvidenceUpdates]

Susceptibility to exacerbation in chronic obstructive pulmonary disease (2010)[NEJM]

Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium (2010)[EvidenceUpdates]

Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD (2010)[EvidenceUpdates]

Association of corticosteroid dose and route of administration with risk of treatment failure in acute exacerbation of chronic obstructive pulmonary disease (2010)[JAMA]

Oral immunotherapy with inactivated nontypeable Haemophilus influenzae reduces severity of acute exacerbations in severe COPD (2010)[EvidenceUpdates]

Cardiovascular safety of tiotropium in patients with COPD (2010)[EvidenceUpdates]

A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease (2010)[EvidenceUpdates]

Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease (2010)[EvidenceUpdates]

Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease (2009)[Evidence Updates]

Statins in COPD: a systematic review(2009)[Evidence Updates]

Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed-treatment comparison meta-analysis (2009) [Evidence Updates]

Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index(2009)[Lancet]

Screening for and early detection of chronic obstructive pulmonary disease (2009)[Lancet]

eTextbooks

Chronic Obstructive Pulmonary Disease (2011) [eMedicine]

Chronic Obstructive Pulmonary Disease (2008)[Mentor]

Diagnosing COPD (2008)[Mentor]

Management of Stable COPD (2008)[Mentor]

Chronic obstructive pulmonary disease: diagnosis (2007) [BMJ Learning]

Chronic obstructive pulmonary disease: treatment (2007) [BMJ Learning]

Clinical Queries

Are you aware of an association between longterm Seretide Treatment(in doses recommended for COPD) and joint pains / arthropathy? (2011)[ATTRACT]

There appears to be a high prevalence of osteopenia/osteoporosis in patients with COPD which is multifactorial. Are there any firm recommendations on DEXA Scanning +/- starting biphosphonate treatments in this group of individuals? (2011)[ATTRACT]

Are there any trials - in COPD - of patients being started directly on dual therapy (as opposed to monotherapy and stepping up when COPD progresses)..? (2011)[ATTRACT]

What evidence is there that beta blockers should be used with caution in COPD? (2011)[ATTRACT]

what should the first line antibiotic be for patients with COPD? (2010)[ATTRACT]

With patients with COAD and PaO2 less than 55-60 mmHg, does home oxygen in addition to 'medical management' compared with medical management alone reduce mortality by 12 months? (2009)[TRIPanswers]

When should a patient on high dose inhaled steroids for COPD have a DXA scan? (2009)[TRIPAnswers]

What is the evidence for long term benefit of long acting beta agonists, inhaled steroid and long acting anticholinergic agents in COPD at 2 years and 5 years? (2008) [TRIP answers]

Are there any studies comparing tiotropium with long-acting beta agonists (e.g. salmeterol and formoterol) in the treatment of COPD? (2008) [TRIP answers]

Patient Information

Chronic obstructive pulmonary disease. (2012) [NHS Choices] NEW

Chronic obstructive pulmonary disease (COPD) (2011)[BUPA]

COPD (2009)[MedlinePlus]

Inhalers for Chronic Obstructive Pulmonary Disease (2009)[Patient UK]

Important

1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at questions@attract.wales.nhs.uk or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.