Monday, 17 February 2014


Evidence Based Reports

Comparative Effectiveness Review, Combination Therapy Versus Intensification of Statin Monotherapy: An Update (2013)[AHRQ] NEW
Ezetimibe (Ezetrol) in combination with a statin for reduction of cardiovascular risk in coronary heart disease (2013) [National Horizon Scanning Centre] NEW

Statins and cognitive function: a systematic review (2013) [DARE] NEW

Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery (2012)[Cochrane] NEW

Statins for the primary prevention of cardiovascular disease (2012)[Cochrane] updated

HMG CoA reductase inhibitors (statins) for kidney transplant recipients (2012)[Cochrane] updated

Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis (2012)[DARE] NEW

Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations (2012)[DARE] NEW

Statin therapy and the risk of intracerebral hemorrhage: a meta-analysis of 31 randomized controlled trials (2012)[DARE] NEW

Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis (2012)[DARE] NEW

Statins for age-related macular degeneration (2011) [Cochrane] updated

Statins for women with polycystic ovary syndrome not actively trying to conceive (2011)[Cochrane]

Statins for multiple sclerosis (2011) [Cochrane]

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials (2011)[DARE] NEW

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials (2011)[DARE] NEW

Statins and prevention of infections: systematic review and meta-analysis of data from large randomised placebo controlled trials (2011)[DARE] NEW

Statins for children with familial hypercholesterolemia (2010)[Cochrane]

Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65229 participants (2010)[DARE]

Effect of statins pretreatment on periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention: a meta-analysis (2010)[DARE]

Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis (2010)[DARE]

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis (2008)[Cochrane]

Statins for the prevention of dementia (2008)[Cochrane]

Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review (2009)[DARE]

Statin therapy and risk of developing type 2 diabetes: a meta-analysis (2009) [DARE]

Statins for the prevention and treatment of infections: a systematic review and meta-analysis (2009)[DARE]

The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials (2009)[DARE]

Statins for secondary prevention in elderly patients: a hierarchical Bayesian meta-analysis (2008)[DARE]

Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials (2008)[DARE]

The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials (2008)[DARE]

Statins and cancer: a meta-analysis of case-control studies (2008)[DARE]

Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients (2008)[DARE]

Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30 000 patients (2008)[DARE]

Statins for infection and sepsis: a systematic review of the clinical evidence (2008)[DARE]

Statin use and development of atrial fibrillation: a systematic review and meta-analysis of randomized clinical trials and observational studies (2008)[DARE]

Clinical Guidelines

Lipid modification - primary and secondary CVD prevention (2008)[CKS]

Lipid modification (2008)[NICE]

Recent articles in core journals

Statin use and reduced cancer-related mortality (2012)[NEJM]

Effect of two intensive statin regimens on progression of coronary disease (2011) [NEJM]

Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. (2011) [NEJM]

Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. (2011)[JAMA]

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials (2010)[Lancet]

Meta-analysis: Statin Therapy Does Not Alter the Association Between Low Levels of High-Density Lipoprotein Cholesterol and Increased Cardiovascular Risk (2010)[Annals of Internal Medicine]

Statin use and the prevention of venous thromboembolism: a meta-analysis (2010)[Int J Clin Pract]


Statins (2010)[GP Notebook]

Clinical Queries

Does the use of statins for primary prevention reduce mortality from CVD in patients >80 years? (2013)[ATTRACT] NEW

What is the most recent evidence regarding whether statins can cause memory loss or dementia? (last search 2005)Is there any evidence that statins help patients establish dementia particularly vascular dementia? (2012)[ATTRACT] NEW

Which statin is safest in renal failure? (2011) [TRIPanswers]

What is the current guidance on statin treatment for primary prevention in patients with calculated 10-yr CVD risk < 20% but Total cholesterol/HDL ratio > 6.0? (2010)[ATTRACT]

Patient Information

Statins (2013)[BUPA Health Information] NEW

Cholesterol-lowering medicines, statins (2012)[NHS Choices]

Statins and Other Lipid Lowering Drugs (2011)[Patient UK]


1. If you are a Welsh Primary Care Professional with a clinical query send it to ATTRACT online or email us at or call 01495 332343.
2. If you would like to comment on this CME topic, or suggest a new topic for ATTRACTcme, go to the comments hyperlink below.Statins for the treatment of dementia (2009)[Cochrane]

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